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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often characterized as a focus on the practical aspects of designing a study that include the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from different geographical regions. This type of heterogeneity, which is essential for pragmatic trials to be reliable and lessen the chance of bias is also essential. However excessive heterogeneity could cause problems with the design of the trial.

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Legality

Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. The software is available on mobile devices and in a variety of languages. Despite its infancy it has already established itself as a premier casino gaming platform. Wolves is one of the most recent releases that is a 5-reel slot machine with a hefty RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they should not be used in lieu for explanation studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study that includes recruitment, design, implementation of the intervention and follow-up.

There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.