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Pragmatic trials are those that are designed to inform the real-world practice of clinical. They are typically focused on the practical aspects of the study design, including the recruitment and consent process in adherence, as well as the use of commonly available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and included participants from different geographical regions. This type of heterogeneity is required for
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cool training] pragmatic trials to be valid, and it also reduces the chance of bias in the results. However, too much heterogeneity, can cause problems with the trial design.
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Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. Its software is designed to work with mobile devices and supports different languages. It has been recognized as one of the leading gaming platforms for casinos despite its relative youth. Wolves is one of the latest games that is a 5-reel slot machine with a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. Usually, they are ordered by policymakers and practitioners to inform their decisions. They can also be used to assess the causality of an intervention and its results. However, they should not be used in lieu for the use of explanation studies.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatism. It is important to remember, however, that the majority were conducted in primary-care settings.