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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are often described by their focus on practical aspects of designing a study, including recruitment and consent, adherence and the use routinely available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. A high degree of heterogeneity, however could cause issues with the trial design.
Pragmatic Play is also a major player in the live casino market, offering an extensive selection of table games that are classic such as Blackjack and Roulette in various variations. The company's live studios in Romania and Malta provide a genuine gambling experience for players and offer an extensive selection of virtual betting options. The company has also created various interactive games to make online gambling enjoyable. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.
Mobile compatibility
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Legality
Pragmatic Play is known for its top-quality games and for providing a superior user experience. Its software is designed to work with mobile devices and supports various languages. It has established itself as one of the top casino gaming platforms despite its relatively young age. The latest releases include Wolves, a 5-reel video slot with a healthful RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are usually requested by practitioners and policymakers to help guide their decisions. They can be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used as a substitute for the use of explanation studies.
The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study which includes recruitment, design, implementation of the intervention, and follow-up.
There is a growing increase in the number of pragmatic trials that have been published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatics. It is important to note that the majority were conducted in primary care settings.