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Pragmatic trials are trials designed to inform real-world clinical practice. They are often described by their focus on practical aspects of design, including the recruitment process and consent, adhering and the use routinely available equipment.
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Pragmatic is a software company that offers a broad range of casino games available on online gambling platforms. Its iGaming solutions are used by the top operators and casinos that are located in the land. The company offers front-end site design tools, analysis and promotions, marketing security, payment systems, customer support and bug reporting. The company also offers a safe environment with high-quality graphics, games and security.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from different geographic areas. This type of heterogeneity is essential for practical trials to be valid and also reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.
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Mobile compatibility
Pragmatic Play, a relatively new player in the field of casinos online, has earned an enviable reputation for its mobile-friendly slot machines. Their games are optimized for mobile devices, and run using HTML5 technology. They are also regulated and certified by trusted gaming authorities, which ensure fairness and transparency. This is a great indicator
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In addition to their mobile-friendly slots, Pragmatic Play also offers table games and live dealer casinos. The company is licensed and regulated by a variety of governing bodies, including the Malta Gaming Authority and UK Gambling Commission. The games are protected by the latest encryption technology, and the company's security team is always ready to assist players resolve any issues they may have.
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Legality
Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. Its software can be used on mobile devices and in a variety of languages. Despite its infancy it has established itself as a top casino gaming platform. Wolves is one of the latest games, a 5-reel slot machine with a hefty RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-world situations and have the highest external validity. Usually, they are ordered by policymakers and practitioners to guide their decisions. They can also be a great method of determining the causality between the intervention and its effects. However, they should not, be used to replace explanatory studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study that includes recruitment, design, delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.