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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized as focusing on practical aspects of study design that include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographic areas. This type of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can result in issues with the design of the trial.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are typically requested by practitioners and policymakers in order to guide their decisions. They also provide a useful method of determining the cause-effect relationship between an intervention and its results. They should, however, not be used to replace explanatory studies.

The pragmatism idea is controversial, and 프라그마틱 게임 there are questions regarding whether pragmatic trials could replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic study, including recruitment, design, delivery of the intervention and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary-care settings.