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Pragmatic trials are those that are designed to inform real-world clinical practice. They are often characterized by a focus on the practical aspects of research design, like the recruitment and consent process as well as adherence to the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from various geographical areas. This kind of heterogeneity, that is crucial for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.
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Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work on mobile devices and supports different languages. Despite its relatively young age it has established itself as a leading gaming platform for casinos. Wolves is one of the most recent releases that is a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are usually commissioned by policymakers and practitioners to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. However, they should not be used in lieu for explanation studies.
The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic research study, including the recruitment, design, and delivery of the intervention and follow-up.
There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the issue of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.